Endocrine Abstracts

Hypocalcemic cardiomyopathy due to hypoparathyroidism is a very rare condition which responds favorably to vitaminocalcic treatment.We report the case of a 50 years old man who presented to our unit for general fatigue, apathy and cough lasting several years with a worsening during the last months, there was biological evidence of hypoparathyroidism with profound hypocalcemia (21 mg/l) hyperphosphoremia (53 mg/l) and undetectable PTH levels the CT scan s...

The GH/IGF axis has been implicated in the pathogenesis of retinopathy in diabetic subjects, the aim of this study is to evaluate the prevalence of diabetic retinopathy in hypersomatotropic patients.Subjects and methods: Twenty four hypersomatotropic patients (12 females, 12 males mean age =49 years, mean hypersomatotropic duration =11 years) have diabetes for 7.25 years in average. To search for diabetic retinopathy a funduscopy was performed in all pat...

Although GH has been implicated in the pathogenesis of retinopathy in diabetic subjects, the frequency of retinopathy in diabetic acromegalic subjects is deemed to be rare. The aim of our study is to evaluate the prevalence of retinopathy in hypersomatotropic patients.Subjects and methods: In total, 40 acromegalic diabetic patients (21 M, 19 F, mean age=50 years) underwent funduscopy to search for diabetic retinopathyResults: Among...

Clinical presentation of pituitary adenomas is influenced by age of patients and stage of the tumour at diagnosis. In this study we intended to analyse the features of pituitary adenomas in old patients.Subjects and methods: It is a retro- and prospective study concerning 37 patients (19F/18M) aged 60 years and over harbouring a pituitary adenoma, these patients were divided into two groups:Group 1 (G1): Patients with invasive and/or giant tum...

Male prolactinomas are rare and considered as bad responders to medical treatment compared to female cases. Our aim was to evaluate response of pituitary macrolesions secreting prolactin (PRL) to dopamine agonists. Our population was composed of 34 men (mean age =36.6 years) with a diagnosis of macroprolactinomas: mean tumor size =35.5 mm (12 – 118) and mean PRL =2505 ng/ml (132 – 19996). Bromocriptine was used with a mean dose of 22.94 mg/day (3.75 – 80) and a ...

The efficacy of Levothyroxine suppressive therapy in thyroid nodules is still controversial; the aim of this study is to evaluate the effect of levothyroxine on nodule volume.Subjects and methods: Ninety three euthyroid patients (92 females, mean age =43.7 years) harboring multindular (n=53) or solitary (n=40) nodules hare been treated for at least 6 months with thyroid hormones (Levothyroxine), the nodule size is assessed by it’s maxi...

Chlorpyrifos (CPF) is a worldwide used organophosphate insecticide for controlling many types of pests in the household, farm and residential settings. It has the potential to negatively affect the reproductive system and fertility. Nigella sativa has been used both as seeds or oil to promote health and fight disease. Hence, the present work was undertaken to evaluate the possible protective role of Nigella sativa oil (NSO) against chlorpyrifos induced reproductive toxicity in...

Introduction: Pituitary somatotrop adenomas are very rare in children and adolescents. They are supposed to be more invasive (invasion of cavernous sinuses or meninges±compression of adjacent neural structures) than adults’ones. We aimed to analyze their characteristics, and their complications.Patients and subjects: are studied subjects whose clinical symptoms began before 20 years old. They all had biological, hormonal, ophthalmological, radi...

Introduction: Prolactinomas are more invasive in males. Giant (≥4 cm) and huge (≥6 cm) ones are relatively rare in literature, but in our population they are nearly common.Aim: We have taken our 20 last cases to analyze their radiological aspects, and their endocrine, neurological and ophthalmological complications.Methods: All of them had clinical exam, hormonal, ophthalmological, and radiological exploration based on ...

Glucose abnormalities are frequent in hyperthyroidism; the aim of our study is to determine the predisposing factors of glucose disturbances in hyperthyroidism.Subjects and methods: It is a retro and prospective study including 263 hyperthyroid subjects, patients having fasting glycaemia <1 g/l and/or glycaemia after OGTT <1.40 g/l (G1) were compared to patients having fasting glycaemia ≥1 g/l and/or glycaemia after OGTT ≥1.40 g/l (G2...